Dried Blood Spots: Analysis and Applications.

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Dried Blood Spots: Analysis and Applications.

Anal Chem. 2012 Nov 21;

Authors: Demirev PA

Abstract
This literature review highlights recent advances and challenges in applying dried blood spots (DBS) as a cumulative technique for sample acquisition, transport, archiving, and prospective/retrospective bioanalysis on a large scale. The technique is minimally invasive, requiring microliters of typically peripheral blood, it is inexpensive, and easy to multiplex and automate. DBS handling and logistics, e.g., storage and shipment at room temperature, allow its deployment even in resource-poor settings. DBS samples are compatible with a large number of bioanalytical methods, among them chromatography, mass spectrometry, DNA and immunoassays. The range of established and emerging DBS applications is vast, to name only a few: large scale neonatal screening, preclinical drug development for lead validation, toxicokinetic (TK) and pharmacokinetic (PK) studies, clinical pharmacology, targeted and non-targeted metabolic profiling, therapeutic drug monitoring (TDM), forensic toxicology, doping or environmental contaminant control, microbiological and epidemiological disease surveillance.

PMID: 23171435 [PubMed - as supplied by publisher]

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