Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-? Signaling.

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Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-? Signaling.

Neuron. 2013 May 8;78(3):456-68

Authors: Yu XM, Gutman I, Mosca TJ, Iram T, Ozkan E, Garcia KC, Luo L, Schuldiner O

Abstract
Axon pruning during development is essential for proper wiring of the mature nervous system, but its�regulation remains poorly understood. We have identified an immunoglobulin superfamily (IgSF) transmembrane protein, Plum, that is cell autonomously required for axon pruning of mushroom body (MB) ? neurons and for ectopic synapse refinement at the developing neuromuscular junction in�Drosophila. Plum promotes MB ? neuron axon pruning by regulating the expression of Ecdysone Receptor-B1, a key initiator of axon pruning. Genetic analyses indicate that Plum acts to facilitate signaling of Myoglianin, a glial-derived TGF-?, on MB ? neurons upstream of the type-I TGF-? receptor Baboon. Myoglianin, Baboon, and Ecdysone Receptor-B1 are also required for neuromuscular junction ectopic synapse refinement. Our study highlights both IgSF proteins and TGF-? facilitation as key promoters of developmental axon elimination and demonstrates a mechanistic conservation between MB axon pruning during metamorphosis and the refinement of ectopic larval neuromuscular connections.

PMID: 23664613 [PubMed - in process]

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