Subversion of innate immune responses by bacterial hindrance of NF-?B pathway.

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Subversion of innate immune responses by bacterial hindrance of NF-?B pathway.

Cell Microbiol. 2012 Feb;14(2):155-67

Authors: Le Negrate G

Abstract
Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-?B) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-?B in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-?B signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-?B signalling, which in turn usurp the host inflammatory response.

PMID: 22044780 [PubMed - indexed for MEDLINE]

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