Antiretroviral activity of protease inhibitors against Toxoplasma gondii.

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Antiretroviral activity of protease inhibitors against Toxoplasma gondii.

Rev Inst Med Trop Sao Paulo. 2013 Jan-Feb;55(1):65-7

Authors: Monzote L, Rodr�guez M, Alfonso Y, Cox R

Abstract
The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 �g/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.

PMID: 23328729 [PubMed - indexed for MEDLINE]

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