Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans.

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Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans.

J Appl Physiol. 2013 Jun 6;

Authors: Gump BS, McMullan DR, Cauthon DJ, Whitt JA, Del Mundo JD, Letham T, Kim PJ, Friedlander GN, Pingel J, Langberg H, Carroll CC

Abstract
Through an unknown mechanism the cyclooxygenase (COX) inhibitor acetaminophen (APAP) alters tendon mechanical properties in humans when consumed during exercise. Interleukin-6 (IL-6) is produced by tendon during exercise and is a potent stimulator of collagen synthesis. In non-tendon tissue, IL-6 is upregulated in presence of COX-inhibitors and may contribute to alterations in extracellular matrix turnover, possibly due to inhibition of prostaglandin E2 (PGE2). We evaluated the effects of APAP on IL-6 and PGE2 in human Achilles peritendinous tissue after 1-hour of treadmill exercise. Subjects were randomly assigned to a placebo (n=8, 26�1 y) or APAP (n=8, 25�1 y) group. Each subject completed a non-exercise and exercise experiment consisting of 6-hours of microdialysis. Drug (APAP, 1000 mg) or placebo was administered in a double-blind manner during both experiments. PGE2 and IL-6 were determined via enzyme immunoassay and APAP via high performance liquid chromatography. In subjects given APAP, peritendinous APAP levels increased to 4.08�0.65 ?g?ml(-1) (p<0.05). PGE2 did not increase with exercise in either group (p>0.05), nor was PGE2 significantly reduced in the APAP group. IL-6 levels increased with exercise in both groups (p<0.05), but this increase was greater in the APAP group (p<0.05). Our findings suggest that APAP enhances tendon IL-6 production after exercise. Peak levels of APAP obtained in the peritendinous space were 2-fold lower than values reported in plasma or skeletal muscle.. These findings provide insight into the effects of APAP on tendon and provide novel information on the kinetics of APAP in tendon tissue after oral APAP consumption.

PMID: 23743397 [PubMed - as supplied by publisher]

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