Cardiovascular adverse effects of anti-inflammatory drugs.

Cardiovascular adverse effects of anti-inflammatory drugs.

Antiinflamm Antiallergy Agents Med Chem. 2012 Dec 31;

Authors: Roubille C, Martel-Pelletier J, Davy JM, Haraoui B, Pelletier JP

Abstract
Anti-inflammatory drugs consist of non-steroidal anti-inflammatory drugs (NSAIDs) including non-selective nsNSAIDs, aspirin, and cyclooxygenase-2 (COX-2)-selective inhibitors also referred to as coxibs, and glucocorticoids (GCs). They are worldwide prescribed drugs for many musculoskeletal conditions, such as osteoarthritis and inflammatory rheumatic diseases. Anti-inflammatory drugs can exert deleterious effects on the cardiovascular system, excluding aspirin. NSAIDs, especially coxibs, have been demonstrated to increase cardiovascular risk and have generated many concerns leading to the reassessment of their benefit/risk ratio. GCs may also induce cardiovascular events, but evidence seems to be less clear. Before prescribing these drugs, an assessment of cardiovascular risk may be judicious.In this review, anti-inflammatory drugs, coxibs, nsNSAIDs and GCs, and the risk of cardiovascular events will be discussed.

PMID: 23286294 [PubMed - as supplied by publisher]

dna-pk coxinhibitors c-met inhibitors