Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

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Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9

Authors: Finlay MR, Griffin RJ

Abstract
Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.

PMID: 22835870 [PubMed - indexed for MEDLINE]

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